Concr machine learning approach predicts tissue of origin from mutation features

05 May 2023

This study, presented at AACR Annual Meeting 2023, demonstrates the potential for a Concr DNA-based machine learning algorithm to improve prognosis of patients with cancer of unknown primary, by aiding diagnosis of tissue of origin. 

Cancer of Unknown Primary (CUP) is a clinical entity with poor prognosis, where patients present with metastatic tumours for which the primary tissue of origin cannot be readily determined

The current standard of care is dependent on determining the primary tissue of origin with radiological investigations, tumour marker assessment and biopsy.

This study will be extended further by applying this approach to large, independent datasets derived from metastatic samples and liquid biopsies from CUP patient cohorts.

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Abstract for this study was published in Cancer Research